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All Bonefill bone replacements of bovine origin are manufactured with bones of animals from the Brazilian herd tracked by the SISBOV system. As per the geographic risk regulations issued by the International Zoosanitary Code and the Scientific Steering Committee of the European Union (SSCEC of August 2005), Brazil is Bovine Spongiform Encephalopathy (BSE)-free. However , according to Administrative Rule 516/97 even Brazil declaring itself Bovine Spongiform Encephalopathy-free, the processing to which the products are submitted are known to effectively inactivate the BSE agent, and the animals used to manufacture Bonefill products are registered in the Brazilian bovine and bubaline traceability system - SISBOV, every product of bovine origin, even remotely, carries a risk of transmitting BSE.